Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 20/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.53 |
| ▸ | CCR5 | P51681 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4428604 | 1.00 | CCR2 (0.57) | CCR2KCNH2CCR5 | |
| SCHEMBL4428600 | 1.00 | CCR2 (0.57) | CCR2KCNH2CCR5 | |
| Bromide SCHEMBL5033806 | 0.98 | CCR2 (0.56) | CCR2KCNH2CCR5 | |
| SCHEMBL5029702 | 0.92 | CCR2 (0.59) | CCR2KCNH2CCR5 | |
| Bromide SCHEMBL4424202 | 0.90 | CCR2 (0.58) | CCR2KCNH2CCR5 | |
| SCHEMBL4414981 | 0.90 | CCR2 (0.69) | CCR2KCNH2CCR5 | |
| SCHEMBL4414974 | 0.90 | CCR2 (0.69) | CCR2KCNH2CCR5 | |
| SCHEMBL4417166 | 0.90 | CCR2 (0.69) | CCR2KCNH2CCR5 | |
| Bromide SCHEMBL4416510 | 0.89 | CCR2 (0.67) | CCR2KCNH2CCR5 | |
| SCHEMBL4419883 | 0.84 | CCR2 (0.74) | CCR2KCNH2CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606255-B1 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2009-11-11 | — | — | EP | disclosed |
| EP-2098508-A1 | Cyclic derivatives as modulators of chemokine receptor activity | Bristol-Myers Squibb Company (US) | 2009-09-09 | — | — | EP | disclosed |