Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.44 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.44 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 4/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.36 |
| ▸ | USP14 | P54578 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3209072 | 0.93 | MTNR1A (0.44) | MTNR1AMTNR1BKCNA3CKS1BSKP1 | |
| SCHEMBL4477066 | 0.90 | SLC2A1 (0.46) | MTNR1AMTNR1BKCNA3CKS1BSKP1 | |
| SCHEMBL3154477 | 0.88 | MTNR1A (0.44) | MTNR1AMTNR1BKCNA3CKS1BSKP1 | |
| SCHEMBL4491260 | 0.80 | MTNR1A (0.47) | MTNR1AMTNR1BKCNA3CKS1BSKP1 | |
| SCHEMBL3148938 | 0.80 | SLC2A1 (0.41) | MTNR1AMTNR1BKCNA3CKS1BSKP1 | |
| SCHEMBL3551289 | 0.80 | SLC2A1 (0.51) | KCNA3SLC2A1KDM4D | |
| SCHEMBL3144945 | 0.80 | KCNA3 (0.40) | MTNR1AMTNR1BKCNA3CKS1BSKP1 | |
| SCHEMBL5726714 | 0.78 | SLC2A1 (0.61) | SLC2A1 | |
| SCHEMBL3155389 | 0.78 | MTNR1A (0.48) | MTNR1AMTNR1BSLC2A1 | |
| SCHEMBL1267791 | 0.77 | SLC2A1 (0.40) | MTNR1AMTNR1BKCNA3CKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2136807-A1 | PYRROLO (3, 2, 1-IJ) QUINOLINE-4-ONE DERIVATIVES FOR TREATING TUBERCULOSIS | Glaxo Group Limited (GB) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008125594-A1 | PYRROLO (3, 2, 1-IJ) QUINOLINE-4-ONE DERIVATIVES FOR TREATING TUBERCULOSIS | GLAXO GROUP LIMITED (GB) | 2008-10-23 | — | — | WO | disclosed |