Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 17/20 | 0.64 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.64 |
| ▸ | SMC2 | O95347 | 1/20 | 0.64 |
| ▸ | EGFR | P00533 | 1/20 | 0.64 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.64 |
| ▸ | SMC1A | Q14683 | 1/20 | 0.64 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.64 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.64 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.64 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.55 |
| ▸ | NQO2 | P16083 | 1/20 | 0.55 |
| ▸ | BRAF | P15056 | 5/20 | 0.37 |
| ▸ | CSF1R | P07333 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4415825 | 0.92 | MAP2K1 (0.77) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL569289 | 0.86 | MAP2K1 (0.84) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL29461531 | 0.86 | MAP2K1 (0.84) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL4418419 | 0.85 | MAP2K1 (0.76) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL4421494 | 0.81 | MAP2K1 (0.62) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL20439546 | 0.79 | MAP2K1 (0.84) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL4418359 | 0.79 | MAP2K1 (0.60) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL19141378 | 0.79 | MAP2K1 (0.86) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL19366337 | 0.78 | MAP2K1 (0.81) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| Selumetinib SCHEMBL155456 | 0.78 | MAP2K1 (1.00) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2130536-B1 | N3 alkylated benzimidazole derivatives as mek inhibitors | ARRAY BIOPHARMA INC (US) | 2013-05-08 | — | — | EP | claimed |
| EP-1482932-B1 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS | ARRAY BIOPHARMA INC (US) | 2009-11-25 | — | — | EP | claimed |