Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTR1E | P28566 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4429325 | 1.00 | PDE4A (0.43) | PDE4AALDH1A1KDM4ES1PR3MEN1 | |
| SCHEMBL4441767 | 0.90 | PDE4A (0.41) | PDE4AALDH1A1KDM4ES1PR3MEN1 | |
| SCHEMBL4432376 | 0.90 | PDE4A (0.42) | PDE4AALDH1A1S1PR3MEN1LMNA | |
| SCHEMBL4438606 | 0.88 | PDE4A (0.42) | PDE4AALDH1A1KDM4E | |
| SCHEMBL4434957 | 0.87 | PDE4A (0.42) | PDE4AALDH1A1S1PR3MEN1LMNA | |
| SCHEMBL4435780 | 0.86 | PDE4A (0.43) | PDE4AALDH1A1S1PR3MEN1LMNA | |
| SCHEMBL4429537 | 0.81 | PDE4A (0.47) | PDE4A | |
| SCHEMBL3740264 | 0.80 | PDE4A (0.41) | PDE4AALDH1A1S1PR3MEN1LMNA | |
| SCHEMBL3740262 | 0.80 | PDE4A (0.41) | PDE4AALDH1A1S1PR3MEN1LMNA | |
| SCHEMBL3729934 | 0.80 | PDE4A (0.41) | PDE4AALDH1A1S1PR3MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |