Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | OXTR | P30559 | 2/20 | 0.48 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL63670 | 0.88 | KMT2A (0.64) | MAPTRAB9AGAAMEN1ALDH1A1 | |
| SCHEMBL5316912 | 0.83 | GAA (0.54) | MAPTGAAMEN1ALDH1A1KMT2A | |
| SCHEMBL4905603 | 0.83 | GAA (0.54) | MAPTGAAMEN1ALDH1A1KMT2A | |
| SCHEMBL4907547 | 0.83 | GAA (0.54) | MAPTGAAMEN1ALDH1A1KMT2A | |
| SCHEMBL511573 | 0.82 | RAB9A (0.60) | MAPTCYP2C9CYP2C19RAB9AGAA | |
| SCHEMBL82476 | 0.80 | KMT2A (0.51) | MAPTGAAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3094416 | 0.76 | GAA (0.45) | MAPTGAAMEN1KMT2ATP53 | |
| SCHEMBL16373718 | 0.76 | GAA (0.59) | MAPTGAAMEN1KMT2ATP53 | |
| SCHEMBL3094410 | 0.76 | GAA (0.45) | MAPTGAAMEN1KMT2ATP53 | |
| SCHEMBL3190543 | 0.76 | GAA (0.45) | MAPTGAAMEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |