Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.49 |
| ▸ | AGTR1 | P30556 | 9/20 | 0.43 |
| ▸ | AGTR2 | P50052 | 9/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4442664 | 0.95 | LTB4R2 (0.42) | LTB4R2AGTR1AGTR2 | |
| SCHEMBL2967794 | 0.90 | LTB4R2 (0.50) | LTB4R2AGTR1AGTR2 | |
| SCHEMBL2967788 | 0.90 | LTB4R2 (0.47) | LTB4R2AGTR1AGTR2 | |
| SCHEMBL2970034 | 0.84 | FEN1 (0.41) | LTB4R2AGTR1AGTR2 | |
| SCHEMBL841569 | 0.81 | AGTR1 (0.43) | LTB4R2AGTR1AGTR2 | |
| SCHEMBL2966088 | 0.80 | LTB4R2 (0.47) | LTB4R2AGTR1AGTR2 | |
| SCHEMBL2966085 | 0.80 | LTB4R2 (0.45) | LTB4R2AGTR1AGTR2 | |
| SCHEMBL840539 | 0.80 | AGTR1 (0.44) | LTB4R2AGTR1AGTR2 | |
| SCHEMBL2969856 | 0.77 | LTB4R2 (0.52) | LTB4R2AGTR1AGTR2 | |
| SCHEMBL840019 | 0.76 | AGTR1 (0.40) | LTB4R2AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132187-A2 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | Theravance, Inc. (US) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008097459-A2 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | THERAVANCE, INC. (US) | 2008-08-14 | — | — | WO | disclosed |