Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 4/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | UTS2R | Q9UKP6 | 4/20 | 0.45 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.44 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.44 |
| ▸ | GABBR2 | O75899 | 3/20 | 0.44 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4438449 | 0.87 | CACNA1A (0.56) | CNR2CACNA1ACACNA2D1CACNA1BCACNB1 | |
| SCHEMBL4617540 | 0.87 | CYP2C19 (0.55) | CACNA1ACACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL4431819 | 0.84 | CYP2C19 (0.55) | CNR2UTS2RCACNA1ACACNA2D1CACNA1B | |
| SCHEMBL4441848 | 0.81 | CACNA1A (0.57) | PPARGCACNA1ACACNA2D1CACNB1CYP2C9 | |
| SCHEMBL10955012 | 0.80 | TACR1 (0.59) | CNR2UTS2RLMNARHOCRHOA | |
| SCHEMBL1980002 | 0.79 | KMT2A (0.55) | PPARGPPARAGABBR2GABBR1CYP2C9 | |
| SCHEMBL11080075 | 0.78 | CES2 (0.47) | CNR2 | |
| SCHEMBL7485566 | 0.78 | FFAR1 (0.56) | CNR2PPARGCACNA1ACACNA2D1CACNA1B | |
| SCHEMBL4432755 | 0.77 | AKR1C3 (0.51) | PPARGPPARACACNA1ACACNA2D1CACNB1 | |
| SCHEMBL23080122 | 0.77 | CES2 (0.50) | CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |