SCHEMBL442971

SCHEMBL442971

Oc1c(Cl)cc(Br)cc1Cl

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 6/20 0.58
HSD17B10 Q99714 6/20 0.58
CYP3A4 P08684 4/20 0.58
TTR P02766 3/20 0.58
RECQL P46063 3/20 0.58
ALDH1A1 P00352 3/20 0.58
THRB P10828 3/20 0.52
ALOX15 P16050 3/20 0.50
ALOX12 P18054 3/20 0.50
SMN1; SMN2 Q16637 3/20 0.50
HIF1A Q16665 3/20 0.50
CYP1A2 P05177 2/20 0.50
CYP2C19 P33261 2/20 0.50
TDP1 Q9NUW8 1/20 0.50
CYP2C9 P11712 1/20 0.50
HPGD P15428 4/20 0.46
MAPK1 P28482 3/20 0.46
MEN1 O00255 5/20 0.44
MAPT P10636 5/20 0.44
KMT2A Q03164 5/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4644670 0.86 TSHR (0.65) TSHRHSD17B10CYP3A4TTRRECQL
SCHEMBL16599884 0.86 TSHR (0.43) TSHRHSD17B10CYP3A4TTRRECQL
SCHEMBL11488034 0.83 HSD17B10 (0.48) TSHRHSD17B10CYP3A4TTRRECQL
SCHEMBL4291280 0.82 THRB (0.48) TSHRHSD17B10CYP3A4TTRRECQL
SCHEMBL9149669 0.82 TSHR (0.40) TSHRHSD17B10CYP3A4TTRRECQL
SCHEMBL528819 0.82 TSHR (0.40) TSHRHSD17B10CYP3A4TTRRECQL
SCHEMBL930155 0.82 MEN1 (0.46) TSHRHSD17B10CYP3A4TTRRECQL
SCHEMBL8822890 0.80 HSP90AA1 (0.48) TSHRHSD17B10CYP3A4TTRRECQL
SCHEMBL22777741 0.80 HSD17B10 (0.61) TSHRHSD17B10CYP3A4TTRRECQL
SCHEMBL11590889 0.78 TSHR (0.37) TSHRHSD17B10CYP3A4TTRRECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 233 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114113370-B Analysis method of aromatic halogenated disinfection byproducts in water 东南大学 2024-03-26 CN claimed
CN-117358067-A Oil-water separation film based on benzoxazine derivative, preparation method and application 陕西科技大学 2024-01-09 CN claimed
CN-114113370-A Analysis method of aromatic halogenated disinfection byproducts in water 东南大学 2022-03-01 CN claimed
CN-109081981-B Durable mildew-proof plastic-wood composite material and preparation method thereof 黄山美森新材料科技股份有限公司 2021-02-09 CN claimed
CN-109081981-A A kind of durable mildewproof plastic-wood composite material and preparation method 黄山美森新材料科技有限公司 2018-12-25 CN claimed
CN-105693032-B A kind of bio-pharmaceuticals factory organic wastewater treating system and its processing method 江苏建筑职业技术学院 2018-05-25 CN claimed
CN-106124646-A A kind of detect the method for polarity phenol chloro/bromo disinfection byproduct (DBP) in water 南京大学 2016-11-16 CN claimed
CN-105693032-A Biological pharmaceutical factory organic wastewater treatment system and treatment method 江苏建筑职业技术学院 2016-06-22 CN claimed
EP-1543061-A1 METHOD OF PREPARING TRANSPARENT SILICONE-CONTAINING COPOLYCARBONATES GENERAL ELECTRIC COMPANY (US) 2005-06-22 EP claimed
US-6833422-B2 Interfacial polymerization of polycarbonates with polysiloxanes, then endcapping to form haze-free polycarbonatepolysiloxane copolymers GENERAL ELECTRIC COMPANY 2004-12-21 US claimed
WO-2004016674-A1 METHOD OF PREPARING TRANSPARENT SILICONE-CONTAINING COPOLYCARBONATES GENERAL ELECTRIC COMPANY (US) 2004-02-26 WO claimed
US-20040039145-A1 Method of preparing transparent silicone-containing copolycarbonates GENERAL ELECTRIC COMPANY 2004-02-26 US claimed
US-6576739-B2 Conversion of the hindered bisphenol to the corresponding bischloroformate and subsequent treatment with an amine catalyst and an aqueous base to effect polymerization by hydrolysis and condenstation of bischloroformate groups GENERAL ELECTRIC COMPANY 2003-06-10 US claimed
US-20020111456-A1 Method of polycarbonate preparation SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2002-08-15 US claimed
WO-2001085825-A2 METHOD OF POLYCARBONATE PREPARATION GENERAL ELECTRIC COMPANY (US) 2001-11-15 WO claimed
EP-0073100-A1 Beta-lactam compounds, their preparation and their use BEECHAM GROUP PLC (GB) 1983-03-02 EP claimed
CN-112805005-B Thyroxine receptor beta agonist compounds 拓臻股份有限公司 2026-05-12 CN disclosed
EP-3840755-B1 THYROID HORMONE RECEPTOR BETA AGONIST COMPOUNDS TERNS INC (US) 2026-02-18 EP disclosed
US-4178447-A Novel synthesis of 3,3-substituted dihydrobenzisothiazole-1,1-dioxides and -2,3-dihydronaphtho-1,2-thiazine-1,1-dioxides POLAROID CORPORATION (US) 1979-12-11 US disclosed
US-3973014-A Thiolphosphoric acid ester insecticide CIBA-GEIGY CORPORATION (US) 1976-08-03 US disclosed