Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.56 |
| ▸ | PDE5A | O76074 | 7/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5430238 | 0.85 | F2RL3 (0.64) | F2RL3PDE5ACYP2D6CYP1A2CYP3A4 | |
| SCHEMBL3245414 | 0.76 | F2RL3 (0.67) | F2RL3PDE5ACYP2D6CYP1A2CYP3A4 | |
| SCHEMBL4427239 | 0.74 | F2RL3 (0.56) | F2RL3PDE5ACYP2D6CYP1A2CYP3A4 | |
| SCHEMBL4424821 | 0.74 | PDE5A (0.67) | F2RL3PDE5ACYP2D6CYP1A2CYP3A4 | |
| SCHEMBL13865175 | 0.74 | F2RL3 (0.63) | F2RL3PDE5ACYP2D6CYP1A2CYP3A4 | |
| SCHEMBL363569 | 0.72 | F2RL3 (1.00) | F2RL3PDE5AALDH1A1MAPK1KDM4E | |
| SCHEMBL29403731 | 0.72 | F2RL3 (1.00) | F2RL3PDE5AALDH1A1MAPK1KDM4E | |
| SCHEMBL18427929 | 0.72 | F2RL3 (0.69) | F2RL3PDE5ACYP2D6CYP1A2CYP3A4 | |
| SCHEMBL4424864 | 0.71 | F2RL3 (0.52) | F2RL3PDE5ACYP2D6CYP1A2CYP3A4 | |
| SCHEMBL27630149 | 0.71 | PDE5A (0.67) | F2RL3PDE5ACYP2D6CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934311-B1 | NEW HETEROCYCLYLMETHYL-SUBSTITUTED PYRAZOL DERIVATES | BAYER HEALTHCARE AG (DE) | 2009-05-13 | — | — | EP | disclosed |