Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 16/20 | 0.56 |
| ▸ | TAS1R1 | Q7RTX1 | 16/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4429982 | 0.84 | TAS1R3 (0.52) | TAS1R3TAS1R1HDAC3HDAC1HDAC2 | |
| SCHEMBL447540 | 0.83 | TAS1R3 (0.60) | TAS1R3TAS1R1HDAC3HDAC1HDAC2 | |
| SCHEMBL4247496 | 0.81 | TAS1R3 (0.57) | TAS1R3TAS1R1HDAC3HDAC1HDAC2 | |
| SCHEMBL6419803 | 0.74 | TAS1R3 (0.50) | TAS1R3TAS1R1HDAC3HDAC1HDAC2 | |
| SCHEMBL705448 | 0.73 | TAS1R3 (1.00) | TAS1R3TAS1R1HDAC3HDAC1HDAC2 | |
| SCHEMBL447778 | 0.72 | TAS1R3 (0.52) | TAS1R3TAS1R1HDAC3HDAC1HDAC2 | |
| SCHEMBL709047 | 0.71 | TAS1R3 (1.00) | TAS1R3TAS1R1HDAC3HDAC1HDAC2 | |
| SCHEMBL445061 | 0.70 | TAS1R3 (0.70) | TAS1R3TAS1R1HDAC3HDAC1HDAC2 | |
| SCHEMBL447539 | 0.70 | TAS1R3 (0.56) | TAS1R3TAS1R1HDAC3HDAC1HDAC2 | |
| SCHEMBL4255578 | 0.70 | TAS1R3 (0.49) | TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099442-A1 | METHOD OF USING HISTONE DEACETYLASE INHIBITORS AND MONITORING BIOMARKERS IN COMBINATION THERAPY | PHARMACYCLICS, INC. (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008082856-A1 | METHOD OF USING HISTONE DEACETYLASE INHIBITORS AND MONITORING BIOMARKERS IN COMBINATION THERAPY | PHARMACYCLICS, INC. (US) | 2008-07-10 | — | — | WO | disclosed |