Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3602618 | 0.77 | CYP2D6 (0.41) | KCNH2SLC2A1SIGMAR1MEN1KMT2A | |
| SCHEMBL3621089 | 0.66 | KCNH2 (0.47) | KCNH2 | |
| SCHEMBL3611864 | 0.65 | KCNH2 (0.41) | KCNH2PTPN11 | |
| SCHEMBL3611173 | 0.65 | KCNH2 (0.41) | KCNH2PTPN11 | |
| SCHEMBL3611172 | 0.65 | KCNH2 (0.41) | KCNH2PTPN11 | |
| SCHEMBL5432490 | 0.61 | PTPN11 (0.35) | KCNH2PTPN11 | |
| SCHEMBL14372223 | 0.61 | CSF1R (0.34) | KCNH2PTPN11 | |
| SCHEMBL3618668 | 0.61 | CSF1R (0.35) | KCNH2PTPN11 | |
| SCHEMBL5047828 | 0.60 | KCNH2 (0.47) | KCNH2 | |
| SCHEMBL5262771 | 0.60 | PTPN11 (0.47) | KCNH2SIGMAR1PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137195-A1 | TRICYCLIC NITROGEN CONTAINING HETEROCYCLES AS ANTIBACTERIAL AGENTS | Glaxo Group Limited (GB) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008128953-A1 | TRICYCLIC NITROGEN CONTAINING HETEROCYCLES AS ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2008-10-30 | — | — | WO | disclosed |