Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4432129 | 0.90 | MRGPRX4 (0.43) | MRGPRX4RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL3729438 | 0.81 | NPC1 (0.50) | MRGPRX4RAB9ANPC1KMT2ALMNA | |
| SCHEMBL3735490 | 0.74 | MRGPRX4 (0.47) | MRGPRX4RAB9ANPC1TDP1KDM4E | |
| SCHEMBL3729435 | 0.72 | MAOB (0.47) | RAB9ANPC1LMNAMAPTNPSR1 | |
| SCHEMBL3735487 | 0.70 | MAOB (0.51) | MRGPRX4RAB9ANPC1KMT2ALMNA | |
| SCHEMBL4432452 | 0.67 | P2RX7 (0.40) | MRGPRX4KMT2ALMNAMAPTNPSR1 | |
| SCHEMBL3789100 | 0.64 | MRGPRX4 (0.41) | MRGPRX4RAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3747705 | 0.64 | MRGPRX4 (0.47) | MRGPRX4TDP1MAPTALDH1A1 | |
| SCHEMBL2134167 | 0.63 | HTR2C (0.56) | — | |
| SCHEMBL30744738 | 0.63 | MRGPRX4 (0.63) | MRGPRX4RAB9ANPC1TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |