Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 6/20 | 0.61 |
| ▸ | EHMT1 | Q9H9B1 | 6/20 | 0.61 |
| ▸ | KDR | P35968 | 3/20 | 0.59 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.59 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.59 |
| ▸ | ATM | Q13315 | 2/20 | 0.57 |
| ▸ | EGFR | P00533 | 2/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.56 |
| ▸ | FLT1 | P17948 | 1/20 | 0.56 |
| ▸ | SPIN1 | Q9Y657 | 2/20 | 0.55 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.55 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.55 |
| ▸ | RET | P07949 | 2/20 | 0.55 |
| ▸ | KIT | P10721 | 1/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4419423 | 1.00 | EHMT2 (0.61) | EHMT2EHMT1KDREPHA2EPHB4 | |
| SCHEMBL4427357 | 0.99 | EHMT2 (0.60) | EHMT2EHMT1KDREPHA2EPHB4 | |
| SCHEMBL4426202 | 0.94 | EHMT2 (0.70) | EHMT2EHMT1KDREPHB4EGFR | |
| SCHEMBL4431962 | 0.93 | EHMT2 (0.69) | EHMT2EHMT1KDREGFRFGFR1 | |
| SCHEMBL4430442 | 0.93 | EHMT2 (0.69) | EHMT2EHMT1KDREGFRFGFR1 | |
| SCHEMBL4417717 | 0.90 | KDR (0.61) | KDREPHA2EPHB4EGFRFGFR1 | |
| SCHEMBL4423943 | 0.86 | EHMT2 (0.59) | EHMT2EHMT1KDREGFRFGFR1 | |
| SCHEMBL30408709 | 0.85 | ENPP1 (0.67) | EHMT2EHMT1KDREPHA2EPHB4 | |
| SCHEMBL4178028 | 0.85 | ENPP1 (0.67) | EHMT2EHMT1KDREPHA2EPHB4 | |
| SCHEMBL18744742 | 0.85 | ENPP1 (0.67) | EHMT2EHMT1KDREPHA2EPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7498335-B2 | Method of producing an antiangiogenic or vascular permeability reducing effect | ASTRAZENECA AB (CH) | 2009-03-03 | — | — | US | disclosed |
| EP-1218353-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2007-10-17 | — | — | EP | disclosed |
| EP-1272185-B1 | USE OF QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ASTRAZENECA AB (SE) | 2005-07-27 | — | — | EP | disclosed |