Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | NQO2 | P16083 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | PDE2A | O00408 | 1/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
| ▸ | CTSA | P10619 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27781264 | 0.88 | ABL1 (0.32) | ABL1GRM2MAPK14HSD11B1DPP4 | |
| SCHEMBL4431468 | 0.88 | TAAR1 (0.36) | ABL1GRM2MAPK14DPP4 | |
| SCHEMBL4175707 | 0.85 | DPP4 (0.38) | ABL1GRM2KDM4EALDH1A1GLA | |
| SCHEMBL4171143 | 0.85 | ABL1 (0.33) | ABL1GRM2KDM4EALDH1A1GLA | |
| SCHEMBL4441851 | 0.84 | ADORA2A (0.39) | KDM4EALDH1A1DPP4CTSA | |
| SCHEMBL4172328 | 0.78 | PDE2A (0.43) | ABL1NQO2HSD11B1PDE2APDE10A | |
| SCHEMBL4181231 | 0.78 | CYP1A2 (0.41) | ALDH1A1MAPK14MAPT | |
| SCHEMBL4174349 | 0.76 | ABL1 (0.36) | ABL1GRM2KDM4EALDH1A1GLA | |
| SCHEMBL4177843 | 0.75 | GRM2 (0.37) | ABL1GRM2ALDH1A1GLAMAPK14 | |
| SCHEMBL27781195 | 0.75 | ABL1 (0.40) | ABL1GRM2NQO2HSD11B1PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137186-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008118468-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2008-10-02 | — | — | WO | disclosed |