SCHEMBL4433085

SCHEMBL4433085

C#Cc1cc(CN)cc(F)c1NS(C)(=O)=O.C#Cc1cc(CN)cc(F)c1NS(C)(=O)=O

nearest known ligand 0.53

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ADRA2C P18825 1/20 0.35
ADRA1A P35348 1/20 0.35
ADRA1B P35368 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL953341 1.00 ADRA2C (0.35) ADRA2CADRA1AADRA1B
Hydrochloric Acid SCHEMBL3772755 0.99 ADRA2C (0.35) ADRA2CADRA1AADRA1B
SCHEMBL4433082 0.89 ADRA2C (0.32) ADRA2CADRA1AADRA1B
SCHEMBL15959176 0.87 MAPT (0.32)
SCHEMBL954083 0.86 ADRA2C (0.35) ADRA2CADRA1AADRA1B
SCHEMBL955620 0.85 ADRA2C (0.42) ADRA2CADRA1AADRA1B
Hydrochloric Acid SCHEMBL3788306 0.83 ADRA2C (0.41) ADRA2CADRA1AADRA1B
SCHEMBL955664 0.80 ADRA2C (0.39) ADRA2CADRA1AADRA1B
SCHEMBL5278076 0.78 ADRA2C (0.38) ADRA2CADRA1AADRA1B
SCHEMBL2005661 0.78 ADRA2C (0.38) ADRA2CADRA1AADRA1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2054411-A1 NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST; AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME Amorepacific Corporation (KR) 2009-05-06 EP disclosed
WO-2008013414-A1 NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST; AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AMOREPACIFIC CORPORATION (KR) 2008-01-31 WO disclosed