Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SHBG | P04278 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL967470 | 0.91 | — | — | |
| SCHEMBL967276 | 0.85 | L3MBTL1 (0.49) | L3MBTL1MEN1KMT2ASLC6A2SLC6A4 | |
| SCHEMBL970095 | 0.83 | L3MBTL1 (0.51) | L3MBTL1MEN1KMT2ASLC6A2SLC6A4 | |
| SCHEMBL4439403 | 0.82 | L3MBTL1 (0.37) | L3MBTL1MEN1KMT2ASLC6A2SLC6A4 | |
| SCHEMBL1932588 | 0.81 | L3MBTL1 (0.41) | L3MBTL1LMNA | |
| SCHEMBL967635 | 0.81 | L3MBTL1 (0.54) | L3MBTL1MEN1KMT2ASLC6A2SLC6A4 | |
| SCHEMBL1290745 | 0.79 | SLC6A4 (0.42) | L3MBTL1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL18172949 | 0.79 | L3MBTL1 (0.41) | L3MBTL1MEN1KMT2ASLC6A2SLC6A4 | |
| SCHEMBL16322297 | 0.79 | L3MBTL1 (0.39) | L3MBTL1MEN1KMT2ASLC6A2SLC6A4 | |
| SCHEMBL3742608 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124951-A1 | 5-CYAN0-4- (PYRROLO Ý2, 3B¨PYRIDINE-3-YL) -PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | Vertex Pharmaceuticals Incorporated (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008079346-A1 | 5-CYAN0-4- (PYRROLO [2, 3B] PYRIDINE-3-YL) -PYRIMIDINE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-07-03 | — | — | WO | disclosed |