Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CASR | P41180 | 3/20 | 0.41 |
| ▸ | MTTP | P55157 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | CCR2 | P41597 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.40 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4429248 | 1.00 | KMT2A (0.43) | KMT2AMEN1ALOX5EPHX2ALDH1A1 | |
| SCHEMBL4433516 | 0.96 | KMT2A (0.43) | KMT2AMEN1ALOX5EPHX2ALDH1A1 | |
| SCHEMBL4434528 | 0.96 | KMT2A (0.43) | KMT2AMEN1ALOX5EPHX2ALDH1A1 | |
| SCHEMBL4432901 | 0.95 | KDM4E (0.42) | KMT2AMEN1ALOX5EPHX2ALDH1A1 | |
| SCHEMBL4429519 | 0.94 | KDM4E (0.43) | KMT2AMEN1ALOX5EPHX2ALDH1A1 | |
| SCHEMBL4432373 | 0.94 | KDM4E (0.43) | KMT2AMEN1ALOX5EPHX2ALDH1A1 | |
| SCHEMBL4429756 | 0.88 | PDE4A (0.42) | KMT2AMEN1ALDH1A1KDM4ECCR2 | |
| SCHEMBL4434762 | 0.88 | PDE4A (0.42) | KMT2AMEN1ALDH1A1KDM4ECCR2 | |
| SCHEMBL4430301 | 0.88 | EPHX2 (0.44) | KMT2AMEN1ALOX5EPHX2ALDH1A1 | |
| SCHEMBL4435541 | 0.88 | EPHX2 (0.44) | KMT2AMEN1ALOX5EPHX2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |