Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3883019 | 0.88 | SMN1; SMN2 (0.46) | SMN1; SMN2THRBGABRA1GABRG2GABRB3 | |
| SCHEMBL4434623 | 0.83 | SMN1; SMN2 (0.49) | SMN1; SMN2THRBL3MBTL1PLA2G2AALDH1A1 | |
| SCHEMBL1643301 | 0.82 | POLB (0.49) | SMN1; SMN2THRBGABRA1GABRG2GABRB3 | |
| SCHEMBL1645639 | 0.80 | SMN1; SMN2 (0.47) | SMN1; SMN2THRBGABRA1GABRG2GABRB3 | |
| SCHEMBL3886901 | 0.78 | CYP19A1 (0.45) | SMN1; SMN2THRBL3MBTL1ALDH1A1MAPT | |
| SCHEMBL1645179 | 0.78 | MAPT (0.46) | SMN1; SMN2THRBGABRA1GABRG2GABRB3 | |
| SCHEMBL1645322 | 0.77 | SMN1; SMN2 (0.68) | SMN1; SMN2THRBL3MBTL1ALDH1A1MAPT | |
| SCHEMBL1646571 | 0.76 | LMNA (0.45) | SMN1; SMN2THRBALDH1A1MAPTMEN1 | |
| SCHEMBL3885596 | 0.74 | CYP19A1 (0.47) | SMN1; SMN2THRBL3MBTL1ALDH1A1MAPT | |
| SCHEMBL1644733 | 0.73 | HTT (0.48) | SMN1; SMN2THRBL3MBTL1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097413-A1 | 2-[(2-SUBSTITUTED)-IND0LIZIN-3-YL]-2-OXO-ACETAMIDE DERIVATIVES AS ANTIFUNGAL AGENTS | F2G Limited (GB) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008062182-A1 | 2- [ (2-SUBSTITUTED) -IND0LIZIN-3-YL] -2-OXO-ACETAMIDE DERIVATIVES AS ANTIFUNGAL AGENTS | F2G LTD (GB) | 2008-05-29 | — | — | WO | disclosed |