SCHEMBL4433744

SCHEMBL4433744

Cc1ccccc1-c1nc2c(C)cccc2cc1CCOc1ncnc2[nH]cnc12

nearest known ligand 0.53

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 19/20 0.53
ATM Q13315 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4437295 0.95 PIK3CD (0.49) PIK3CD
SCHEMBL4182575 0.90 PIK3CD (0.55) PIK3CDATM
SCHEMBL4178301 0.83 PIK3CD (0.61) PIK3CDATM
SCHEMBL10250951 0.83 PIK3CD (0.47) PIK3CDATM
SCHEMBL4174017 0.82 PIK3CD (0.52) PIK3CD
SCHEMBL4180797 0.80 PIK3CD (0.55) PIK3CD
SCHEMBL788378 0.79 PIK3CD (0.75) PIK3CDATM
SCHEMBL4172242 0.78 PIK3CD (0.49) PIK3CDATM
SCHEMBL788765 0.76 PIK3CD (0.51) PIK3CD
SCHEMBL21679533 0.76 PIK3CD (0.47) PIK3CD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2137186-A1 HETEROCYCLIC COMPOUNDS AND THEIR USES Amgen Inc. (US) 2009-12-30 EP disclosed
WO-2008118468-A1 HETEROCYCLIC COMPOUNDS AND THEIR USES AMGEN INC. (US) 2008-10-02 WO disclosed