Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.61 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 7/20 | 0.44 |
| ▸ | NPC1 | O15118 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2104945 | 0.85 | HTR2C (0.45) | HTR2CALDH1A1KDM4EHPGDRAB9A | |
| SCHEMBL3543512 | 0.79 | IRAK4 (0.64) | HTR2CALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3541979 | 0.77 | HTR2C (0.56) | HTR2CALDH1A1KDM4EHPGDRAB9A | |
| SCHEMBL31206570 | 0.75 | HTR2C (0.58) | HTR2CHPGDRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4398770 | 0.74 | PIN1 (0.44) | HTR2CPIN1ALDH1A1HPGDRAB9A | |
| SCHEMBL26707398 | 0.74 | HPGD (0.61) | HTR2CHPGDCNR1RAB9ANPC1 | |
| SCHEMBL3545567 | 0.73 | HTR2C (0.67) | HTR2CHPGDCNR1RAB9ANPC1 | |
| SCHEMBL2225857 | 0.73 | HDAC1 (0.55) | HTR2CPIN1 | |
| SCHEMBL3543198 | 0.73 | HTR2C (0.63) | HTR2CPIN1ALDH1A1KDM4EHPGD | |
| SCHEMBL29944217 | 0.73 | HTR2C (0.63) | HTR2CPIN1ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504413-B2 | N-(4-(imidazo[1,2A]pyridin-YL)phenethyl)benzamide inhibitors of the mitotic kinesin CENP-E for treating certain cellular proliferation diseases | CYTOKINETICS, INC. (US) | 2009-03-17 | — | — | US | disclosed |
| CN-101023057-A | Certain chemicals, compositions, and methods | CYTOKINETICS INC (US) | 2007-08-22 | — | — | CN | disclosed |