Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 18/20 | 0.70 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17502295 | 0.83 | KCNH2 (1.00) | KCNH2 | |
| SCHEMBL4425220 | 0.78 | KCNH2 (0.69) | KCNH2 | |
| Hydrochloric Acid SCHEMBL4432839 | 0.76 | KCNH2 (0.43) | KCNH2GRIN2BRXRAGRIN1 | |
| SCHEMBL4429968 | 0.76 | NCOA3 (0.48) | KCNH2 | |
| SCHEMBL4423160 | 0.76 | KCNH2 (0.48) | KCNH2 | |
| Hydrochloric Acid SCHEMBL4429057 | 0.76 | KCNH2 (0.42) | KCNH2GRIN2BRXRAGRIN1 | |
| SCHEMBL4423505 | 0.75 | KCNH2 (0.51) | KCNH2GRIN2BRXRAGRIN1 | |
| SCHEMBL4424298 | 0.75 | RXRA (0.48) | KCNH2GRIN2BRXRAGRIN1 | |
| SCHEMBL17502288 | 0.74 | KCNH2 (1.00) | KCNH2 | |
| SCHEMBL4427774 | 0.74 | KCNH2 (0.67) | KCNH2GRIN2BRXRAGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358165-B1 | IMIDAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2009-03-11 | — | — | EP | disclosed |