Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 10/20 | 0.55 |
| ▸ | JAK3 | P52333 | 4/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.53 |
| ▸ | CLK2 | P49760 | 4/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.53 |
| ▸ | PAK4 | O96013 | 3/20 | 0.53 |
| ▸ | PIM1 | P11309 | 3/20 | 0.53 |
| ▸ | PRKACA | P17612 | 3/20 | 0.53 |
| ▸ | CDK2 | P24941 | 3/20 | 0.53 |
| ▸ | FLT3 | P36888 | 3/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.53 |
| ▸ | CDK9 | P50750 | 3/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.53 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.53 |
| ▸ | STK3 | Q13188 | 3/20 | 0.53 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.53 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27627560 | 0.85 | SYK (0.64) | SYKJAK3MAP4K4CLK2DYRK1A | |
| SCHEMBL2717397 | 0.81 | MAPK9 (0.51) | ROCK2MAPK9ROCK1KDM4EHTT | |
| SCHEMBL2717012 | 0.81 | MAPK9 (0.51) | ROCK2MAPK9ROCK1TDP1 | |
| SCHEMBL8543979 | 0.78 | EIF2AK2 (0.50) | SYKJAK3MAP4K4CLK2DYRK1A | |
| SCHEMBL4435114 | 0.77 | KDR (0.65) | SYKJAK3MAP4K4CLK2DYRK1A | |
| Hydrochloric Acid SCHEMBL6246305 | 0.76 | KDR (0.64) | SYKJAK3MAP4K4CLK2DYRK1A | |
| SCHEMBL5413116 | 0.76 | JAK3 (0.62) | SYKJAK3MAP4K4CLK2DYRK1A | |
| SCHEMBL2715880 | 0.76 | MAPK9 (0.49) | SYKIRAK4MAPK8MAPK9CDK8 | |
| SCHEMBL4560491 | 0.75 | SYK (0.59) | SYKJAK3MAP4K4CLK2DYRK1A | |
| SCHEMBL10242654 | 0.74 | SYK (0.73) | SYKJAK3MAP4K4CLK2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4392348-B2 | — | — | 2009-12-24 | — | — | JP | claimed |
| JP-4338974-B2 | — | — | 2009-10-07 | — | — | JP | claimed |
| JP-2006502118-A | — | — | 2006-01-19 | — | — | JP | claimed |
| EP-1562933-A2 | SUBSTITUTED AMINE DERIVATIVES AND METHODS OF USE IN THE TREATMENT OF ANGIOGENESIS RELATED DISORDERS | Amgen Inc. (US) | 2005-08-17 | — | — | EP | claimed |
| EP-1467721-A2 | SUBSTITUTED AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF ANGIOGENESIS | Amgen Inc. (US) | 2004-10-20 | — | — | EP | claimed |
| JP-2004527499-A | — | — | 2004-09-09 | — | — | JP | claimed |
| WO-2004007481-A2 | SUBSTITUTED AMINE DERIVATIVES AND METHODS OF USE IN THE TREATMENT OF ANGIOGENESIS RELATES DISORDERS | AMGEN INC. (US) | 2004-01-22 | — | — | WO | claimed |
| WO-2002068406-A2 | SUBSTITUTED AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF ANGIOGENESIS | AMGEN INC. (US) | 2002-09-06 | — | — | WO | claimed |
| EP-1585743-A1 | 2-(1H-INDAZOL-6-YLAMINO)- BENZAMIDE COMPOUNDS AS PROTEIN KINASES INHIBITORS USEFUL FOR THE TREATMENT OF OPHTHALMIC DISEASES | PFIZER INC. (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004056806-A1 | 2-(1H-INDAZOL-6-YLAMINO)-BENZAMIDE COMPOUNDS AS PROTEIN KINASES INHIBITORS USEFUL FOR THE TREATMENT OF OPHTALMIC DISEASES | PFIZER INC. (US) | 2004-07-08 | — | — | WO | disclosed |