Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 1/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.45 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | IMPDH2 | P12268 | 4/20 | 0.44 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | F9 | P00740 | 1/20 | 0.40 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2717012 | 0.94 | MAPK9 (0.51) | MAPK9MAPK10SIRT2SIRT3SIRT1 | |
| SCHEMBL3959568 | 0.81 | TGFBR1 (0.43) | MAPK9MAPK10TGFBR1SIRT2SIRT3 | |
| SCHEMBL2716640 | 0.81 | SYK (0.58) | MAPK9MAPK10TGFBR1SIRT2HTT | |
| SCHEMBL2715880 | 0.81 | MAPK9 (0.49) | MAPK9MAPK10TGFBR1SIRT2SIRT3 | |
| SCHEMBL4435120 | 0.81 | SYK (0.55) | MAPK9TDP1KDM4EHTTROCK2 | |
| SCHEMBL2717394 | 0.79 | RAB9A (0.59) | MAPK9MAPK10SIRT2SIRT3SIRT1 | |
| SCHEMBL5078983 | 0.78 | SIRT3 (0.54) | TGFBR1SIRT2SIRT3IMPDH2TDP1 | |
| SCHEMBL479807 | 0.78 | SIRT2 (0.54) | SIRT2SIRT3SIRT1TDP1KDM4E | |
| SCHEMBL28283004 | 0.78 | MAPK8 (0.57) | MAPK9SIRT2SIRT1MAP2K1ROCK2 | |
| SCHEMBL2712559 | 0.77 | PTGS1 (0.56) | TGFBR1KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635556-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | claimed |
| WO-2012061418-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | claimed |