Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.43 |
| ▸ | CCR2 | P41597 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | MTOR | P42345 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4431243 | 1.00 | KDM4E (0.45) | KDM4EMTNR1AMTNR1BCCR2MEN1 | |
| SCHEMBL4431325 | 1.00 | KDM4E (0.45) | KDM4EMTNR1AMTNR1BCCR2MEN1 | |
| SCHEMBL4440449 | 0.95 | KDM4E (0.41) | KDM4EMTNR1AMTNR1BCCR2MEN1 | |
| SCHEMBL4438296 | 0.95 | KDM4E (0.41) | KDM4EMTNR1AMTNR1BCCR2MEN1 | |
| SCHEMBL4434948 | 0.95 | KDM4E (0.41) | KDM4EMTNR1AMTNR1BCCR2MEN1 | |
| SCHEMBL4434661 | 0.92 | KDM4E (0.45) | KDM4EMTNR1AMTNR1BCCR2MEN1 | |
| SCHEMBL4430527 | 0.92 | KDM4E (0.45) | KDM4EMTNR1AMTNR1BCCR2MEN1 | |
| SCHEMBL4440265 | 0.92 | KDM4E (0.45) | KDM4EMTNR1AMTNR1BCCR2MEN1 | |
| Hydrochloric Acid SCHEMBL4429329 | 0.91 | KDM4E (0.44) | KDM4EMTNR1AMTNR1BCCR2MEN1 | |
| Hydrochloric Acid SCHEMBL4440339 | 0.91 | KDM4E (0.44) | KDM4EMTNR1AMTNR1BCCR2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |