Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4438296 | 1.00 | KDM4E (0.41) | KDM4ECNR1CNR2MTNR1AMTNR1B | |
| SCHEMBL4434948 | 1.00 | KDM4E (0.41) | KDM4ECNR1CNR2MTNR1AMTNR1B | |
| SCHEMBL4431325 | 0.95 | KDM4E (0.45) | KDM4ECNR1MTNR1AMTNR1BMEN1 | |
| SCHEMBL4431243 | 0.95 | KDM4E (0.45) | KDM4ECNR1MTNR1AMTNR1BMEN1 | |
| SCHEMBL4435507 | 0.95 | KDM4E (0.45) | KDM4ECNR1MTNR1AMTNR1BMEN1 | |
| SCHEMBL4436355 | 0.91 | MTNR1A (0.41) | KDM4ECNR1CNR2MTNR1AMTNR1B | |
| SCHEMBL4433172 | 0.91 | MTNR1A (0.41) | KDM4ECNR1CNR2MTNR1AMTNR1B | |
| SCHEMBL4440265 | 0.88 | KDM4E (0.45) | KDM4ECNR1MTNR1AMTNR1BMEN1 | |
| SCHEMBL4434661 | 0.88 | KDM4E (0.45) | KDM4ECNR1MTNR1AMTNR1BMEN1 | |
| SCHEMBL4430527 | 0.88 | KDM4E (0.45) | KDM4ECNR1MTNR1AMTNR1BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |