Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 11/20 | 0.37 |
| ▸ | LMNA | P02545 | 5/20 | 0.37 |
| ▸ | HTT | P42858 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4433726 | 0.94 | HTT (0.37) | PIK3CDLMNAHTTMAPK1SMN1; SMN2 | |
| SCHEMBL4178542 | 0.91 | PIK3CD (0.40) | PIK3CDLMNAHTTCLK4MAP4K4 | |
| SCHEMBL4443103 | 0.88 | LMNA (0.40) | PIK3CDLMNAHTTMAPK1SMN1; SMN2 | |
| SCHEMBL4435767 | 0.88 | MAP4K4 (0.40) | PIK3CDLMNAHTTMAPK1SMN1; SMN2 | |
| SCHEMBL4429984 | 0.88 | PIK3CD (0.37) | PIK3CDLMNAHTTMAPK1SMN1; SMN2 | |
| SCHEMBL4431296 | 0.87 | PIK3CD (0.36) | PIK3CDLMNAHTTMAPK1SMN1; SMN2 | |
| SCHEMBL4443357 | 0.86 | PIK3CD (0.40) | PIK3CDLMNAHTTMAPK1SMN1; SMN2 | |
| SCHEMBL4434206 | 0.85 | HTT (0.38) | PIK3CDLMNAHTTMAPK1SMN1; SMN2 | |
| SCHEMBL4436584 | 0.85 | CLK4 (0.34) | PIK3CDLMNAHTTMAPK1SMN1; SMN2 | |
| SCHEMBL4182144 | 0.85 | MEN1 (0.38) | PIK3CDLMNAHTTCLK4MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137186-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008118468-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2008-10-02 | — | — | WO | disclosed |