Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 8/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.35 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4441783 | 1.00 | P2RX7 (0.38) | P2RX7EP300NR1I2CYP2C9TRPV1 | |
| SCHEMBL4436024 | 0.94 | P2RX7 (0.44) | P2RX7EP300TRPV1 | |
| SCHEMBL4440448 | 0.94 | P2RX7 (0.37) | P2RX7EP300TRPV1TRPV3 | |
| SCHEMBL4434631 | 0.93 | P2RX7 (0.38) | P2RX7EP300TRPV1TRPV3 | |
| SCHEMBL4429672 | 0.93 | P2RX7 (0.38) | P2RX7EP300TRPV1TRPV3 | |
| SCHEMBL4440427 | 0.92 | EP300 (0.39) | P2RX7EP300CYP2C9TRPV1TRPV3 | |
| SCHEMBL4430543 | 0.92 | EP300 (0.39) | P2RX7EP300CYP2C9TRPV1TRPV3 | |
| SCHEMBL4433047 | 0.92 | P2RX7 (0.37) | P2RX7EP300TRPV1TRPV3 | |
| SCHEMBL4440242 | 0.92 | P2RX7 (0.37) | P2RX7EP300TRPV1TRPV3 | |
| SCHEMBL4429561 | 0.92 | P2RX7 (0.37) | P2RX7EP300TRPV1TRPV3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | claimed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | claimed |
| EP-2114867-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107335-A1 | AMINOAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-09-12 | — | — | WO | disclosed |