SCHEMBL4435927

SCHEMBL4435927

CCCCOCc1oc(-c2cccc(C(F)(F)F)c2)nc1C

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 8/20 0.44
PPARG P37231 5/20 0.44
BRD4 O60885 1/20 0.44
HTT P42858 2/20 0.43
RAB9A P51151 2/20 0.43
ALDH1A1 P00352 2/20 0.43
LMNA P02545 1/20 0.43
MAPT P10636 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
UTRN P46939 1/20 0.42
PPARA Q07869 5/20 0.42
VDR P11473 4/20 0.41
ESR1 P03372 2/20 0.41
THRA P10827 2/20 0.41
THRB P10828 2/20 0.41
RXRA P19793 2/20 0.41
ESR2 Q92731 2/20 0.41
NPC1 O15118 1/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13865198 0.83 HTT (0.47) PPARDPPARGBRD4HTTRAB9A
SCHEMBL7668983 0.76 TLR8 (0.43) PPARGRAB9AALDH1A1MAPTUTRN
SCHEMBL6236951 0.73 PPARD (0.79) PPARDPPARGPPARAVDRESR1
SCHEMBL6237121 0.72 PPARD (0.77) PPARDPPARGPPARAVDRESR1
SCHEMBL7654586 0.70 VDR (0.35) PPARDPPARGPPARAVDRESR1
SCHEMBL18003516 0.70 MAPT (0.48) PPARGHTTRAB9AALDH1A1LMNA
SCHEMBL1930103 0.69 MAPT (0.50) PPARGHTTRAB9AALDH1A1LMNA
SCHEMBL18003367 0.69 UTRN (0.44) HTTRAB9AALDH1A1LMNAMAPT
SCHEMBL26070205 0.69 MAPT (0.47) PPARGHTTRAB9AALDH1A1LMNA
SCHEMBL18003404 0.69 TARBP2 (0.58) HTTRAB9AALDH1A1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0934311-B1 NEW HETEROCYCLYLMETHYL-SUBSTITUTED PYRAZOL DERIVATES BAYER HEALTHCARE AG (DE) 2009-05-13 EP disclosed
CN-1241188-A Heterocyclylmethyl-substed pyrazol derivs. BAYER AG (DE) 2000-01-12 CN disclosed
EP-0934311-A2 NEW HETEROCYCLYLMETHYL-SUBSTITUTED PYRAZOL DERIVATES BAYER AG (DE) 1999-08-11 EP disclosed
WO-1998016507-A2 NEW HETEROCYCLYLMETHYL-SUBSTITUTED PYRAZOL DERIVATES AND THEIR USE FOR TREATING CARDIOVASCULAR DISEASES BAYER AKTIENGESELLSCHAFT (DE) 1998-04-23 WO disclosed