Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | POLB | P06746 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.49 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11475873 | 0.85 | NPC1 (0.71) | NPC1SMN1; SMN2KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL4437150 | 0.84 | KDM4E (0.56) | NPC1SMN1; SMN2KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL11819784 | 0.84 | NPC1 (0.77) | NPC1SMN1; SMN2KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL11907383 | 0.83 | NPC1 (0.61) | NPC1SMN1; SMN2KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL11818379 | 0.82 | NPC1 (0.75) | NPC1SMN1; SMN2KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL10733821 | 0.82 | NPC1 (0.75) | NPC1SMN1; SMN2KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL11471717 | 0.80 | SMN1; SMN2 (1.00) | NPC1SMN1; SMN2KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL11908425 | 0.80 | NPC1 (0.71) | NPC1SMN1; SMN2KDM4EHSD17B10ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11817727 | 0.79 | SMN1; SMN2 (0.97) | NPC1SMN1; SMN2KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL11907679 | 0.79 | NPC1 (0.70) | NPC1SMN1; SMN2KDM4EHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132177-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |