Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.43 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4436030 | 0.84 | NPC1 (0.67) | KDM4EHSD17B10ALDH1A1GAAPOLB | |
| SCHEMBL29978999 | 0.82 | KDM4E (0.74) | KDM4EHSD17B10ALDH1A1GAAPOLB | |
| SCHEMBL4437631 | 0.81 | L3MBTL1 (0.53) | KDM4EHSD17B10ALDH1A1GAAPOLB | |
| SCHEMBL4436843 | 0.80 | MEN1 (0.70) | ALDH1A1GAAPOLBL3MBTL1TDP1 | |
| SCHEMBL17395881 | 0.79 | NPC1 (0.68) | KDM4EHSD17B10ALDH1A1GAAPOLB | |
| SCHEMBL4442551 | 0.77 | MAPT (0.46) | KDM4EHSD17B10ALDH1A1GAAPOLB | |
| SCHEMBL4433463 | 0.76 | POLB (0.69) | KDM4EHSD17B10ALDH1A1GAAPOLB | |
| SCHEMBL16993915 | 0.76 | ALDH1A1 (0.44) | KDM4EHSD17B10ALDH1A1GAAPOLB | |
| SCHEMBL16993892 | 0.76 | ALDH1A1 (0.69) | KDM4EHSD17B10ALDH1A1GAAPOLB | |
| SCHEMBL19291257 | 0.76 | KDM4E (0.53) | KDM4EHSD17B10ALDH1A1GAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132177-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis Ag (CH) | 2009-12-16 | — | — | EP | disclosed |
| WO-2008106692-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |