Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.57 |
| ▸ | FBP1 | P09467 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2206314 | 1.00 | KDR (0.57) | KDRFBP1CYP3A4TSHRMAPK1 | |
| SCHEMBL4436143 | 0.83 | KDR (0.67) | KDRAXLMKNK1MKNK2 | |
| SCHEMBL15196374 | 0.77 | KDR (0.54) | KDRDHFR | |
| SCHEMBL16488523 | 0.76 | KDR (0.47) | KDR | |
| SCHEMBL2658253 | 0.76 | KDR (0.47) | KDRFBP1ADORA2AADORA1AXL | |
| SCHEMBL14047248 | 0.75 | ICAM1 (0.41) | KDRFBP1CYP3A4TSHRMAPK1 | |
| SCHEMBL4758591 | 0.75 | KDR (0.36) | KDRFBP1CYP3A4TSHRMAPK1 | |
| SCHEMBL16488513 | 0.75 | KDR (0.57) | KDR | |
| SCHEMBL10297716 | 0.74 | KDR (0.46) | KDRAXLMKNK1MKNK2 | |
| SCHEMBL2210593 | 0.73 | DHFR (0.43) | KDRCYP3A4TSHRMAPK1PDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137177-A2 | AURORA KINASE MODULATORS AND METHOD OF USE | Amgen, Inc (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008124083-A2 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC. (US) | 2008-10-16 | — | — | WO | disclosed |