Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 16/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2206398 | 0.79 | PDE10A (0.54) | PDE10AFLT1KDRCYP1A2CYP3A4 | |
| SCHEMBL1579468 | 0.78 | KDM4E (0.42) | GAAMAPTSMN1; SMN2TDP1CYP3A4 | |
| SCHEMBL4436437 | 0.77 | PDE10A (0.48) | PDE10A | |
| SCHEMBL4165792 | 0.74 | PDE10A (0.44) | PDE10AFLT1KDRCYP1A2CYP3A4 | |
| SCHEMBL4155866 | 0.74 | PDE10A (0.44) | PDE10AFLT1KDRCYP1A2CYP3A4 | |
| SCHEMBL16285128 | 0.72 | PDE10A (0.50) | PDE10AFLT1KDRCYP1A2CYP3A4 | |
| SCHEMBL4775174 | 0.71 | FLT1 (0.60) | PDE10AFLT1KDR | |
| SCHEMBL6098070 | 0.71 | FLT1 (0.60) | PDE10AFLT1KDR | |
| SCHEMBL5245086 | 0.70 | PDE10A (0.56) | PDE10ACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL16445891 | 0.69 | HMGCR (0.56) | MAPTTDP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137177-A2 | AURORA KINASE MODULATORS AND METHOD OF USE | Amgen, Inc (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008124083-A2 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC. (US) | 2008-10-16 | — | — | WO | disclosed |