Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 15/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2206398 | 0.82 | PDE10A (0.54) | PDE10A | |
| SCHEMBL705665 | 0.78 | KDM4E (0.69) | HTTKDM4E | |
| SCHEMBL30870738 | 0.78 | KDM4E (0.69) | HTTKDM4E | |
| SCHEMBL4436440 | 0.77 | PDE10A (0.43) | PDE10A | |
| SCHEMBL5245086 | 0.73 | PDE10A (0.56) | PDE10A | |
| SCHEMBL12793494 | 0.73 | HTT (0.56) | HTTKDM4E | |
| SCHEMBL16285128 | 0.72 | PDE10A (0.50) | PDE10A | |
| SCHEMBL4165792 | 0.72 | PDE10A (0.44) | PDE10A | |
| SCHEMBL4155866 | 0.72 | PDE10A (0.44) | PDE10A | |
| SCHEMBL6098070 | 0.71 | FLT1 (0.60) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137177-A2 | AURORA KINASE MODULATORS AND METHOD OF USE | Amgen, Inc (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008124083-A2 | AURORA KINASE MODULATORS AND METHOD OF USE | AMGEN INC. (US) | 2008-10-16 | — | — | WO | disclosed |