Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | GLA | P06280 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.44 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL941858 | 0.76 | ALDH1A1 (1.00) | ALDH1A1KDM4EGAANPC1RAB9A | |
| SCHEMBL29904585 | 0.76 | ALDH1A1 (1.00) | ALDH1A1KDM4EGAANPC1RAB9A | |
| SCHEMBL10000569 | 0.74 | PDE4B (0.50) | ALDH1A1KDM4EGAAPDE4BKMT2A | |
| SCHEMBL6276708 | 0.73 | ADORA2A (0.60) | ALDH1A1KDM4EGAAADORA2ANPC1 | |
| SCHEMBL7016601 | 0.73 | ALDH1A1 (0.62) | ALDH1A1KDM4EGAAPDE4BNPC1 | |
| SCHEMBL30804562 | 0.72 | KDM4E (0.53) | ALDH1A1KDM4EGAAPDE4BNPC1 | |
| SCHEMBL30804559 | 0.71 | TSHR (0.55) | ALDH1A1KDM4EGAAADORA2AKMT2A | |
| SCHEMBL30804565 | 0.71 | TSHR (0.55) | ALDH1A1KDM4EGAAADORA2AKMT2A | |
| SCHEMBL10028057 | 0.71 | PDE4B (0.56) | ALDH1A1KDM4EGAAPDE4BKMT2A | |
| SCHEMBL8026750 | 0.71 | ALDH1A1 (0.65) | ALDH1A1KDM4EGAAPDE4BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392683-B1 | SUBSTITUTED 4H-CHROMENES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THEIR USE AS ANTICANCER AGENTS | CYTOVIA INC (US) | 2009-12-02 | — | — | EP | disclosed |