Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sofinicline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 known ✓ | P17787 | 20/20 | 1.00 |
| ▸ | CHRNA4 known ✓ | P43681 | 20/20 | 1.00 |
| ▸ | CHRNB4 | P30926 | 20/20 | 1.00 |
| ▸ | CHRNA3 | P32297 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sofinicline SCHEMBL650489 | 1.00 | CHRNB2 (1.00) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| Sofinicline SCHEMBL650490 | 1.00 | CHRNB2 (1.00) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| Sofinicline SCHEMBL22754711 | 1.00 | CHRNB2 (1.00) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| Sofinicline SCHEMBL1560706 | 1.00 | CHRNB2 (1.00) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| Sofinicline SCHEMBL650488 | 1.00 | CHRNB2 (1.00) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| Sofinicline SCHEMBL5096637 | 0.99 | CHRNB2 (0.97) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| Sofinicline SCHEMBL5929684 | 0.99 | CHRNB2 (0.97) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| Sofinicline SCHEMBL5929688 | 0.99 | CHRNB2 (0.97) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| Sofinicline SCHEMBL3913110 | 0.99 | CHRNB2 (0.97) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| Sofinicline SCHEMBL2080581 | 0.92 | CHRNB2 (0.85) | CHRNB2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119476-B1 | Amide derivatives as positive allosteric modulators and methods of use thereof | ABBVIE INC (US) | 2014-03-19 | — | — | EP | disclosed |
| EP-2119476-A2 | Amide derivatives as positive allosteric modulators and methods of use thereof | ABBOTT LABORATORIES (US) | 2009-11-18 | — | — | EP | disclosed |