Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4440875 | 0.95 | NPC1 (0.47) | TSHRKMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL4438408 | 0.95 | NPC1 (0.47) | TSHRKMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL4448649 | 0.95 | NPC1 (0.47) | TSHRKMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL5914916 | 0.84 | NPC1 (0.43) | KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL5914994 | 0.84 | NPC1 (0.43) | KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL5914957 | 0.83 | KMT2A (0.46) | TSHRKMT2AMEN1SMN1; SMN2NPC1 | |
| SCHEMBL5915090 | 0.83 | KMT2A (0.46) | TSHRKMT2AMEN1SMN1; SMN2NPC1 | |
| SCHEMBL27632851 | 0.83 | NPC1 (0.49) | KMT2ANPC1RAB9AL3MBTL1 | |
| SCHEMBL15234415 | 0.82 | TSHR (0.50) | TSHRSMN1; SMN2ALDH1A1L3MBTL1CACNA2D1 | |
| SCHEMBL19399122 | 0.82 | ALDH1A1 (0.48) | TSHRKMT2AKDM4EMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125772-B1 | A PROCESS FOR THE PREPARATION OF DULOXETIN AND NEW KEY INTERMEDIATES FOR USE THEREIN | RICHTER GEDEON NYRT (HU) | 2013-09-11 | — | — | EP | disclosed |
| EP-2125772-A1 | A PROCESS FOR THE PREPARATION OF DULOXETIN AND NEW KEY INTERMEDIATES FOR USE THEREIN | Richter Gedeon NYRT (HU) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008078124-A1 | A PROCESS FOR THE PREPARATION OF DULOXETIN AND NEW KEY INTERMEDIATES FOR USE THEREIN | RICHTER GEDEON NYRT. (HU) | 2008-07-03 | — | — | WO | disclosed |