Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 14/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | PRKDC | P78527 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | TPMT | P51580 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9550827 | 0.88 | ERN1 (0.52) | ERN1KDM4EALDH1A1CYP3A4MAPT | |
| SCHEMBL7371372 | 0.83 | KDM4E (0.49) | ERN1KDM4EALDH1A1CYP3A4MAPT | |
| SCHEMBL790725 | 0.81 | ERN1 (0.54) | ERN1KDM4EALDH1A1CYP3A4MAPT | |
| SCHEMBL5653572 | 0.81 | ALDH1A1 (0.53) | ERN1KDM4EALDH1A1CYP3A4MAPT | |
| SCHEMBL5649150 | 0.80 | KDM4E (0.49) | ERN1KDM4EALDH1A1CYP3A4MAPT | |
| SCHEMBL7279701 | 0.79 | KDM4E (0.44) | ERN1KDM4EALDH1A1CYP3A4MAPT | |
| SCHEMBL4969724 | 0.77 | ERN1 (0.59) | ERN1KDM4EALDH1A1CYP3A4MAPT | |
| SCHEMBL30285913 | 0.77 | ERN1 (0.59) | ERN1KDM4EALDH1A1CYP3A4MAPT | |
| SCHEMBL12154699 | 0.77 | ERN1 (0.54) | ERN1KDM4EALDH1A1CYP3A4MAPT | |
| SCHEMBL22411776 | 0.77 | ALDH1A1 (0.53) | ERN1KDM4EALDH1A1CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110059545-A1 | TIME-TEMPERATURE INDICATOR BASED ON OLIGOMERIC SPIROAROMATICS | FRESHPOINT HOLDINGS SA (CH) | 2011-03-10 | — | — | US | disclosed |
| CN-101646744-A | Time temperature indicator based on oligomeric spiroaromatic compounds | FRESHPOINT HOLDINGS SA CH | 2010-02-10 | — | — | CN | disclosed |
| EP-2121870-A1 | TIME-TEMPERATURE INDICATOR BASED ON OLIGOMERIC SPIROAROMATICS | FRESHPOINT HOLDINGS SA (CH) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008090045-A1 | TIME-TEMPERATURE INDICATOR BASED ON OLIGOMERIC SPIROAROMATICS | FRESHPOINT HOLDINGS SA (CH) | 2008-07-31 | — | — | WO | disclosed |
| US-6951870-B2 | Coumarin derivatives with COMT inhibiting activity | ORION CORPORATION (FI) | 2005-10-04 | — | — | US | disclosed |
| CN-1199963-C | Coumarin derivatives with COMT inhibiting activity | ORION CORP (FI) | 2005-05-04 | — | — | CN | disclosed |
| US-20040110750-A9 | Coumarin derivatives with comt inhibiting activity | ORION CORPORATION (FI) | 2004-06-10 | — | — | US | disclosed |
| EP-1301503-B1 | COUMARIN DERIVATIVES WITH COMT INHIBITING ACTIVITY | ORION CORP (FI) | 2004-02-25 | — | — | EP | disclosed |
| US-20030186975-A1 | Coumarin derivatives with comt inhibiting activity | PYSTYNEN JARMO (FI) | 2003-10-02 | — | — | US | disclosed |
| CN-1440399-A | Coumarin derivatives with COMT inhibiting activity | ORION CORP (FI) | 2003-09-03 | — | — | CN | disclosed |
| EP-1301503-A1 | COUMARIN DERIVATIVES WITH COMT INHIBITING ACTIVITY | ORION CORPORATION (FI) | 2003-04-16 | — | — | EP | disclosed |
| WO-2002002548-A1 | COUMARIN DERIVATIVES WITH COMT INHIBITING ACTIVITY | ORION CORPORATION (FI) | 2002-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110750-A9 | Coumarin derivatives with comt inhibiting activity | COMT, CYP1A1, CYP2D6 | ERN1 858/4885KDM4E 2539/4885ALDH1A1 85/4885 |
| US-20110059545-A1 | TIME-TEMPERATURE INDICATOR BASED ON OLIGOMERIC SPIROAROMATICS | CCND3, CCNT1, SCO2 | ERN1 2191/4885KDM4E 4772/4885ALDH1A1 2009/4885 |
| US-20030186975-A1 | Coumarin derivatives with comt inhibiting activity | COMT, CYP1A1, CYP2D6 | ERN1 858/4885KDM4E 2539/4885ALDH1A1 85/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.