SCHEMBL4437262

SCHEMBL4437262

CC(=O)C(C)(CCl)c1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 2/20 0.47
CYP2C19 P33261 2/20 0.47
KMT2A Q03164 2/20 0.44
MAPT P10636 1/20 0.44
CYP1A2 P05177 3/20 0.42
HDAC3 O15379 1/20 0.41
HDAC4 P56524 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC7 Q8WUI4 1/20 0.41
HDAC2 Q92769 1/20 0.41
HDAC10 Q969S8 1/20 0.41
HDAC11 Q96DB2 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
HDAC9 Q9UKV0 1/20 0.41
HDAC5 Q9UQL6 1/20 0.41
DRD4 P21917 1/20 0.39
OPRM1 P35372 1/20 0.39
DRD3 P35462 1/20 0.39
KCNN4 O15554 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8167581 0.86 HIF1A (0.48) HIF1ACYP2C19KMT2AMAPTCYP1A2
SCHEMBL22341259 0.86 HIF1A (0.48) HIF1ACYP2C19KMT2AMAPTCYP1A2
SCHEMBL22341285 0.86 HIF1A (0.48) HIF1ACYP2C19KMT2AMAPTCYP1A2
SCHEMBL4175632 0.86 HIF1A (0.48) HIF1ACYP2C19KMT2AMAPTCYP1A2
SCHEMBL4437287 0.82 MEN1 (0.47) HIF1ACYP2C19KMT2AMAPTCYP1A2
SCHEMBL28682985 0.82 CYP2C19 (0.48) HIF1ACYP2C19KMT2AMAPTCYP1A2
SCHEMBL4662400 0.80 CYP2C19 (0.47) HIF1ACYP2C19KMT2AMAPTCYP1A2
SCHEMBL7173135 0.80 CYP2C19 (0.52) HIF1ACYP2C19KMT2AMAPTCYP1A2
SCHEMBL16075933 0.80 CYP2C19 (0.47) HIF1ACYP2C19KMT2AMAPTCYP1A2
SCHEMBL29003672 0.79 KCNN4 (0.56) HIF1ACYP2C19KMT2AMAPTCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2134692-A2 QUINOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM FOR SELECTIN INHIBITION Wyeth a Corporation of the State of Delaware (US) 2009-12-23 EP disclosed
WO-2008121817-A2 QUINOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM FOR SELECTIN INHIBITION WYETH (US) 2008-10-09 WO disclosed