Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22341259 | 1.00 | HIF1A (0.48) | HIF1ACYP2C19CYP1A2MAPTKMT2A | |
| SCHEMBL22341285 | 1.00 | HIF1A (0.48) | HIF1ACYP2C19CYP1A2MAPTKMT2A | |
| SCHEMBL8167581 | 0.88 | HIF1A (0.48) | HIF1ACYP2C19CYP1A2MAPTKMT2A | |
| SCHEMBL4437262 | 0.86 | HIF1A (0.47) | HIF1ACYP2C19CYP1A2MAPTKMT2A | |
| SCHEMBL10445351 | 0.84 | HIF1A (0.46) | HIF1ACYP2C19CYP1A2MAPTKMT2A | |
| SCHEMBL17710499 | 0.82 | L3MBTL1 (0.50) | HIF1AMAPTALDH1A1MAPK1KIF11 | |
| SCHEMBL29003672 | 0.81 | KCNN4 (0.56) | HIF1ACYP2C19CYP1A2MAPTKMT2A | |
| SCHEMBL1492728 | 0.81 | CYP2C19 (0.50) | HIF1ACYP2C19CYP1A2MAPTKMT2A | |
| SCHEMBL6758034 | 0.81 | CYP2C19 (0.50) | HIF1ACYP2C19CYP1A2MAPTKMT2A | |
| SCHEMBL23453194 | 0.79 | TAAR1 (0.54) | HIF1ACYP2C19CYP1A2MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903979-B1 | NOVEL COMPOUNDS, THEIR PREPARATION AND THEIR USES | INHIBIKASE THERAPEUTICS INC (US) | 2020-08-19 | — | — | EP | claimed |
| CN-103193620-B | A kind of loxoprofen's key intermediate 2-for preparing is to the method for chloromethyl phenyl propionic acid | ANHUI HERYI CHEMICALS CO., LTD. (CN) | 2015-11-11 | — | — | CN | claimed |
| CN-103193620-A | Method for preparing 2-(4-Chloromethylphenyl) propionic acid as loxoprofen key intermediate | TIANCHANG HERYI PHARMA CO LTD | 2013-07-10 | — | — | CN | claimed |
| CN-103193620-B | A kind of loxoprofen's key intermediate 2-for preparing is to the method for chloromethyl phenyl propionic acid | ANHUI HERYI CHEMICALS CO., LTD. (CN) | 2015-11-11 | — | — | CN | disclosed |
| CN-103193620-B | A kind of loxoprofen's key intermediate 2-for preparing is to the method for chloromethyl phenyl propionic acid | ANHUI HERYI CHEMICALS CO., LTD. (CN) | 2015-11-11 | — | — | CN | disclosed |
| CN-103193620-B | A kind of loxoprofen's key intermediate 2-for preparing is to the method for chloromethyl phenyl propionic acid | ANHUI HERYI CHEMICALS CO., LTD. (CN) | 2015-11-11 | — | — | CN | disclosed |
| EP-2822938-A1 | RODENTICIDAL NORBORMIDE ANALOGUES | Landcare Research New Zealand Limited (NZ) | 2015-01-14 | — | — | EP | disclosed |
| WO-2013133726-A1 | RODENTICIDAL NORBORMIDE ANALOGUES | LANDCARE RESEARCH NEW ZEALAND LIMITED (NZ) | 2013-09-12 | — | — | WO | disclosed |
| CN-103193620-A | Method for preparing 2-(4-Chloromethylphenyl) propionic acid as loxoprofen key intermediate | TIANCHANG HERYI PHARMA CO LTD | 2013-07-10 | — | — | CN | disclosed |
| US-8247608-B2 | Aminoacid derivatives containing a disulfanyl group in the form of mixed disulfanyl and aminopeptidase N inhibitors | PHARMALEADS (FR) | 2012-08-21 | — | — | US | disclosed |
| US-8247609-B2 | Aminoacid derivatives containing a disulfanyl group in the form of mixed disulfanyl and aminopeptidase N inhibitors | Pharamleads (FR) | 2012-08-21 | — | — | US | disclosed |
| US-20090131509-A1 | Aminoacid Derivatives Containing a Disulfanyl Group in the form of Mixed Disulfanyl and Aminopeptidase N Inhibitors | PHARMALEADS (FR) | 2009-05-21 | — | — | US | disclosed |
| US-20090012153-A1 | AMINOACID DERIVATIVES CONTAINING A DISULFANYL GROUP IN THE FORM OF MIXED DISULFANYL AND AMINOPEPTIDASE N INHIBITORS | PHARMALEADS (FR) | 2009-01-08 | — | — | US | disclosed |
| CN-101074242-A | Cells accumulation for sphosphonate analogs of HIV protease inhibitor compound and the same compound | GILEAD SCIENCES INC (US) | 2007-11-21 | — | — | CN | disclosed |
| CN-1313472-C | Cellular Accumulation of Phosphonate Analogs of HIV Protease Inhibitor Compounds and Such Compounds | GILEAD SCIENCES INC (US) | 2007-05-02 | — | — | CN | disclosed |
| CN-1829694-A | quinoline derivatives and their use in therapy | ASTRAZENECA AB (SE) | 2006-09-06 | — | — | CN | disclosed |
| CN-1649885-A | Cellular Accumulation of Phosphonate Analogs of HIV Protease Inhibitor Compounds and Such Compounds | GILEAD SCIENCES INC (US) | 2005-08-03 | — | — | CN | disclosed |
| CN-1433415-A | N-[5-[[[5-alkyl-2-oxazlyl]methyl]thio]-2-thiazolyl] carboxamide inhibitors of cyclin dependent kinases | BRISTOL MYERS SQUIBB CO (US) | 2003-07-30 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131509-A1 | Aminoacid Derivatives Containing a Disulfanyl Group in the form of Mixed Disulfanyl and Aminopeptidase N Inhibitors | HRH4, OPRL1, CNR2 | HIF1A 657/4885CYP2C19 188/4885CYP1A2 343/4885 |
| US-20090012153-A1 | AMINOACID DERIVATIVES CONTAINING A DISULFANYL GROUP IN THE FORM OF MIXED DISULFANYL AND AMINOPEPTIDASE N INHIBITORS | HRH4, CNR2, OPRM1 | HIF1A 739/4885CYP2C19 193/4885CYP1A2 266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.