Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | LTK | P29376 | 1/20 | 0.38 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1823212 | 0.96 | KDM4E (0.52) | KDM4EHSD17B10KMT2AABL1ALDH1A1 | |
| SCHEMBL1825095 | 0.94 | KDM4E (0.54) | KDM4EHSD17B10KMT2AMEN1ABL1 | |
| SCHEMBL4437313 | 0.92 | KMT2A (0.43) | KDM4EHSD17B10KMT2AMEN1ABL1 | |
| SCHEMBL1824677 | 0.88 | KDM4E (0.52) | KDM4EHSD17B10KMT2AMEN1ABL1 | |
| SCHEMBL1825586 | 0.86 | NR4A2 (0.55) | KDM4EHSD17B10KMT2AMEN1ALDH1A1 | |
| SCHEMBL1823309 | 0.84 | KDM4E (0.52) | KDM4EHSD17B10KMT2AMEN1ABL1 | |
| SCHEMBL1823741 | 0.84 | KMT2A (0.58) | KDM4EHSD17B10KMT2AALDH1A1NR4A2 | |
| SCHEMBL1826208 | 0.84 | KDM4E (0.52) | KDM4EHSD17B10KMT2AMEN1ABL1 | |
| SCHEMBL1825548 | 0.82 | KDM4E (0.54) | KDM4EHSD17B10KMT2AMEN1ALDH1A1 | |
| SCHEMBL1825885 | 0.82 | KDM4E (0.49) | KDM4EHSD17B10KMT2AABL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118051-A1 | NEW COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE THEREOF | Chelsea Therapeutics, Inc. (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008097180-A1 | NEW COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE THEREOF | CHELSEA THERAPEUTICS, INC. (US) | 2008-08-14 | — | — | WO | disclosed |