Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4437310 | 0.92 | KDM4E (0.48) | KMT2AABL1KDM4EHSD17B10MEN1 | |
| SCHEMBL1823212 | 0.88 | KDM4E (0.52) | KMT2AABL1KDM4EHSD17B10HPGD | |
| SCHEMBL1825095 | 0.86 | KDM4E (0.54) | KMT2AABL1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL1824677 | 0.80 | KDM4E (0.52) | KMT2AABL1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL1825586 | 0.78 | NR4A2 (0.55) | KMT2AKDM4EHSD17B10SMN1; SMN2MEN1 | |
| SCHEMBL1823309 | 0.76 | KDM4E (0.52) | KMT2AABL1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL1823741 | 0.76 | KMT2A (0.58) | KMT2AKDM4EHSD17B10ALDH1A1FFAR1 | |
| SCHEMBL1826208 | 0.76 | KDM4E (0.52) | KMT2AABL1KDM4EHSD17B10MEN1 | |
| SCHEMBL1825885 | 0.74 | KDM4E (0.49) | KMT2AABL1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL1824122 | 0.74 | KDM4E (0.49) | KMT2AKDM4EHSD17B10MEN1F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118051-A1 | NEW COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE THEREOF | Chelsea Therapeutics, Inc. (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008097180-A1 | NEW COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE THEREOF | CHELSEA THERAPEUTICS, INC. (US) | 2008-08-14 | — | — | WO | disclosed |