Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABHD6 | Q9BV23 | 3/20 | 0.55 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.52 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.52 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 2/20 | 0.47 |
| ▸ | HSD17B3 | P37058 | 4/20 | 0.45 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1956852 | 1.00 | ABHD6 (0.55) | ABHD6DPP8DPP9DPP7HSP90AA1 | |
| SCHEMBL587507 | 0.86 | ABHD6 (0.59) | ABHD6DPP8DPP9DPP7HSD17B3 | |
| SCHEMBL3808915 | 0.86 | ABHD6 (0.59) | ABHD6DPP8DPP9DPP7HSD17B3 | |
| SCHEMBL31598007 | 0.86 | ABHD6 (0.59) | ABHD6DPP8DPP9DPP7HSD17B3 | |
| SCHEMBL29040812 | 0.83 | ABHD6 (0.50) | ABHD6DPP8DPP9DPP7NAMPT | |
| SCHEMBL1263462 | 0.83 | ABHD6 (0.50) | ABHD6DPP8DPP9DPP7NAMPT | |
| SCHEMBL16101941 | 0.83 | NOTUM (0.60) | ABHD6DPP8DPP9DPP7HSP90AA1 | |
| SCHEMBL21591709 | 0.81 | ABHD6 (0.40) | ABHD6DPP8DPP9DPP7HSP90AA1 | |
| SCHEMBL29104006 | 0.81 | SRD5A1 (0.44) | ABHD6DPP8DPP9DPP7HSP90AA1 | |
| SCHEMBL30575059 | 0.80 | DPP8 (0.56) | ABHD6DPP8DPP9DPP7HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125757-A1 | MACROCYCLIC COMPOUNDS AS HCV NS3 PROTEASE INHIBITORS | Novartis AG (CH) | 2009-12-02 | — | — | EP | disclosed |
| EP-2125778-A1 | CERTAIN PYRAZOLINE DERIVATIVES WITH KINASE INHIBITORY ACTIVITY | Millennium Pharmaceuticals, Inc. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008101665-A1 | MACROCYCLIC COMPOUNDS AS HCV NS3 PROTEASE INHIBITORS | NOVARTIS AG (CH) | 2008-08-28 | — | — | WO | disclosed |
| WO-2008079277-A1 | CERTAIN PYRAZOLINE DERIVATIVES WITH KINASE INHIBITORY ACTIVITY | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |