Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 7/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | NT5E | P21589 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4185412 | 0.90 | DPP4 (0.43) | TAAR1ADORA2ADPP4NT5EMEN1 | |
| SCHEMBL27802876 | 0.88 | ADORA2A (0.39) | ADORA2ADPP4NT5EMEN1USP2 | |
| SCHEMBL4441851 | 0.88 | ADORA2A (0.39) | ADORA2ADPP4NT5EMEN1USP2 | |
| SCHEMBL4171148 | 0.85 | ERBB2 (0.42) | ADORA2ADPP4NT5EMEN1USP2 | |
| SCHEMBL4431468 | 0.84 | TAAR1 (0.36) | TAAR1DPP4CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL14047509 | 0.81 | ADORA2A (0.38) | ADORA2ADPP4NT5EMEN1USP2 | |
| SCHEMBL4182457 | 0.78 | NR1H2 (0.51) | ADORA2ANT5EMEN1USP2ALDH1A1 | |
| SCHEMBL16447644 | 0.77 | ADORA2A (0.39) | ADORA2ADPP4NT5EMEN1USP2 | |
| SCHEMBL4172215 | 0.76 | SMN1; SMN2 (0.43) | ADORA2AMEN1USP2ALDH1A1CYP1A2 | |
| SCHEMBL4431751 | 0.76 | MAP4K4 (0.41) | MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137186-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008118468-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2008-10-02 | — | — | WO | disclosed |