Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.39 |
| ▸ | MPO | P05164 | 2/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.38 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1822953 | 0.88 | MRGPRX4 (0.49) | MEN1KMT2AMRGPRX4KDM4EALDH1A1 | |
| SCHEMBL1824443 | 0.86 | FFAR1 (0.43) | MEN1KMT2AMRGPRX4KDM4EALDH1A1 | |
| SCHEMBL1826502 | 0.85 | MEN1 (0.52) | MEN1KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1825548 | 0.85 | KDM4E (0.54) | MEN1KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1823550 | 0.84 | MEN1 (0.54) | MEN1KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1825956 | 0.82 | NR4A2 (0.57) | MEN1KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1827458 | 0.79 | KDM4E (0.51) | MEN1KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1826874 | 0.79 | KMT2A (0.49) | MEN1KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4440066 | 0.78 | KDM4E (0.44) | MEN1KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1827618 | 0.78 | SRD5A2 (0.47) | MRGPRX4KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118051-A1 | NEW COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE THEREOF | Chelsea Therapeutics, Inc. (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008097180-A1 | NEW COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE THEREOF | CHELSEA THERAPEUTICS, INC. (US) | 2008-08-14 | — | — | WO | disclosed |