Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.40 |
| ▸ | FABP3 | P05413 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1827458 | 0.93 | KDM4E (0.51) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1827139 | 0.90 | PPARD (0.43) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1823452 | 0.90 | ADAMTS4 (0.48) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1825956 | 0.86 | NR4A2 (0.57) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1822953 | 0.83 | MRGPRX4 (0.49) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1827618 | 0.82 | SRD5A2 (0.47) | KDM4EALDH1A1MAPT | |
| SCHEMBL4441436 | 0.82 | PTGER1 (0.39) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1826022 | 0.82 | KDM4E (0.54) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1826874 | 0.81 | KMT2A (0.49) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4604582 | 0.80 | MAOB (0.53) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118051-A1 | NEW COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE THEREOF | Chelsea Therapeutics, Inc. (US) | 2009-11-18 | — | — | EP | claimed |
| WO-2008097180-A1 | NEW COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE THEREOF | CHELSEA THERAPEUTICS, INC. (US) | 2008-08-14 | — | — | WO | claimed |