Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.53 |
| ▸ | LCK | P06239 | 5/20 | 0.53 |
| ▸ | TEK | Q02763 | 3/20 | 0.53 |
| ▸ | BRAF | P15056 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.47 |
| ▸ | KIT | P10721 | 4/20 | 0.47 |
| ▸ | SRC | P12931 | 3/20 | 0.47 |
| ▸ | CSF1R | P07333 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4438210 | 0.77 | MAPK14 (0.56) | KDRMAPK14LCKTEKBRAF | |
| SCHEMBL4436387 | 0.74 | MAPK14 (0.59) | KDRMAPK14LCKTEKBRAF | |
| SCHEMBL4439915 | 0.73 | BRAF (0.58) | KDRMAPK14LCKTEKBRAF | |
| SCHEMBL4439947 | 0.73 | BRAF (0.60) | KDRMAPK14LCKTEKBRAF | |
| SCHEMBL4445721 | 0.70 | RAF1 (0.59) | BRAF | |
| SCHEMBL1264642 | 0.69 | TEK (1.00) | KDRMAPK14LCKTEKBRAF | |
| SCHEMBL4446258 | 0.69 | LCK (0.57) | KDRMAPK14LCKTEKBRAF | |
| SCHEMBL5261124 | 0.68 | KDR (0.72) | KDRMAPK14LCKTEKBRAF | |
| SCHEMBL1264834 | 0.67 | KDR (1.00) | KDRMAPK14LCKTEKBRAF | |
| SCHEMBL1268205 | 0.67 | KDR (0.81) | KDRMAPK14LCKTEKBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121692-A1 | SUBSTITUTED HETEROCYCLES AS JANUS KINASE INHIBITORS | Incyte Corporation (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008079965-A1 | SUBSTITUTED HETEROCYCLES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2008-07-03 | — | — | WO | disclosed |