Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.72 |
| ▸ | TEK | Q02763 | 11/20 | 0.72 |
| ▸ | BRAF | P15056 | 5/20 | 0.72 |
| ▸ | LCK | P06239 | 4/20 | 0.72 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.72 |
| ▸ | KIT | P10721 | 2/20 | 0.49 |
| ▸ | CSF1R | P07333 | 2/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5262340 | 0.87 | TEK (0.67) | KDRTEKBRAFLCKMAPK14 | |
| SCHEMBL1264642 | 0.84 | TEK (1.00) | KDRTEKBRAFLCKMAPK14 | |
| SCHEMBL1264883 | 0.83 | KDR (0.75) | KDRTEKBRAFLCKMAPK14 | |
| SCHEMBL1268205 | 0.82 | KDR (0.81) | KDRTEKBRAFLCKMAPK14 | |
| SCHEMBL1265071 | 0.82 | KDR (0.78) | KDRTEKBRAFLCKMAPK14 | |
| SCHEMBL1264672 | 0.81 | KDR (0.72) | KDRTEKBRAFLCKMAPK14 | |
| SCHEMBL2264176 | 0.81 | TEK (1.00) | KDRTEKBRAFLCKMAPK14 | |
| SCHEMBL1264834 | 0.81 | KDR (1.00) | KDRTEKBRAFLCKMAPK14 | |
| SCHEMBL1264860 | 0.79 | TEK (0.75) | KDRTEKBRAFLCKMAPK14 | |
| SCHEMBL1263967 | 0.79 | KDR (0.84) | KDRTEKBRAFLCKMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751136-A2 | NITROGENATED HETEROCYCLIC DERIVATIVES AS PROTEIN KINASE MODULATORS AND USE FOR THE TREATMENT OF ANGIOGENESIS AND CANCER | AMGEN INC. (US) | 2007-02-14 | — | — | EP | claimed |
| WO-2005113494-A2 | NITROGENATED HETEROCYCLIC DERIVATIVES AS PROTEIN KINASE MODULATORS AND USE FOR THE TREATMENT OF ANGIOGENESIS AND CANCER | AMGEN INC. (US) | 2005-12-01 | — | — | WO | claimed |