Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.37 |
| ▸ | PARP11 | Q9NR21 | 3/20 | 0.37 |
| ▸ | PARP1 | P09874 | 3/20 | 0.34 |
| ▸ | HTR5A | P47898 | 1/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.32 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2880311 | 0.88 | PARP10 (0.41) | PARP10PARP11PARP1PNMTASIC3 | |
| SCHEMBL515124 | 0.85 | HTR5A (0.42) | PARP10PARP11PARP1HTR5APNMT | |
| Hydrochloric Acid SCHEMBL31599518 | 0.83 | HTR5A (0.41) | PARP10PARP11PARP1HTR5APNMT | |
| SCHEMBL3115966 | 0.74 | SRC (0.53) | HTR5ASRC | |
| SCHEMBL31722113 | 0.70 | PARP1 (0.42) | PARP10PARP11PARP1HTR5ASRC | |
| SCHEMBL4870530 | 0.70 | PARP10 (0.43) | PARP10PARP11PARP1PNMTASIC3 | |
| SCHEMBL2261586 | 0.70 | PARP10 (0.39) | PARP10PARP11PARP1GRM5 | |
| SCHEMBL652655 | 0.70 | PARP10 (0.43) | PARP10PARP11PARP1PNMTSRC | |
| SCHEMBL3956228 | 0.67 | PARP1 (0.33) | PARP10PARP1 | |
| SCHEMBL4869350 | 0.67 | PARP10 (0.41) | PARP10PARP11PARP1PNMTASIC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121657-A1 | SULFONYLATED HETEROCYCLES USEFUL FOR MODULATION OF THE PROGESTERONE RECEPTOR | Wyeth (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008109056-A1 | SULFONYLATED HETEROCYCLES USEFUL FOR MODULATION OF THE PROGESTERONE RECEPTOR | WYETH (US) | 2008-09-12 | — | — | WO | disclosed |