Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 11/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4441662 | 0.92 | HSD17B10 (0.37) | PDE4DHSD17B10PTGS1PTGS2KDM4E | |
| SCHEMBL885259 | 0.90 | PDE4D (0.40) | PDE4DHSD17B10KDM4EPOLBGAA | |
| SCHEMBL885392 | 0.89 | PDE4D (0.42) | PDE4DHSD17B10PTGS1PTGS2KDM4E | |
| SCHEMBL885164 | 0.89 | PDE4D (0.41) | PDE4DHSD17B10PTGS1PTGS2KDM4E | |
| SCHEMBL4429229 | 0.89 | PDE4D (0.48) | PDE4DERN1GAANPC1SMN1; SMN2 | |
| SCHEMBL885299 | 0.87 | PDE4D (0.43) | PDE4DERN1GAANPC1MAPT | |
| SCHEMBL885169 | 0.84 | PDE4D (0.52) | PDE4D | |
| SCHEMBL4427860 | 0.82 | NPC1 (0.39) | PDE4DERN1GAANPC1 | |
| SCHEMBL885375 | 0.80 | PDE4D (0.41) | PDE4DHSD17B10KDM4EPOLBGAA | |
| SCHEMBL885394 | 0.80 | PDE4D (0.40) | PDE4DERN1GAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125736-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | Leo Pharma A/S (DK) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008077404-A1 | SUBSTITUTED ACETOPHENONES USEFUL AS PDE4 INHIBITORS | LEO PHARMA A/S (DK) | 2008-07-03 | — | — | WO | disclosed |