Ammonia Solution, Strong

Ammonia Solution, Strong

SCHEMBL4438526

CN1c2cc(C(F)(F)F)ccc2CCC1C(N)=O.N

nearest known ligand 0.45

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 1/20 0.43
SRD5A1 P18405 1/20 0.42
TRPV1 Q8NER1 4/20 0.41
NOTUM Q6P988 1/20 0.41
HDAC3 O15379 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC7 Q8WUI4 1/20 0.41
HDAC2 Q92769 1/20 0.41
HDAC10 Q969S8 1/20 0.41
HDAC11 Q96DB2 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
HDAC5 Q9UQL6 1/20 0.41
XIAP P98170 1/20 0.40
BIRC2 Q13490 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
MAPT P10636 1/20 0.40
CYP2C9 P11712 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL429127 0.99 CNR2 (0.44) CNR2SRD5A1TRPV1NOTUMHDAC3
SCHEMBL431484 0.84 TRPV1 (0.43) CNR2SRD5A1TRPV1NOTUMHDAC3
Ammonia Solution, Strong SCHEMBL4552719 0.78 HDAC3 (0.49) HDAC3HDAC1HDAC7HDAC2HDAC10
SCHEMBL429270 0.76 HDAC3 (0.50) HDAC3HDAC1HDAC7HDAC2HDAC10
SCHEMBL28780022 0.76 NOTUM (0.43) CNR2SRD5A1TRPV1NOTUMHDAC3
SCHEMBL432288 0.75 MTNR1A (0.53) NOTUMMAPTGAA
SCHEMBL431259 0.75 SRD5A1 (0.41) CNR2SRD5A1TRPV1NOTUMHDAC3
SCHEMBL27760761 0.73 SRD5A1 (0.42) CNR2SRD5A1TRPV1NOTUMHDAC3
SCHEMBL3113512 0.70 MTNR1A (0.35)
SCHEMBL3113867 0.68 MTNR1A (0.35)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2134678-A2 N-(5, 6, 7, 8-TETRAHYDRONAPHTHALEN-1-YL) UREA DERIVATIVES AND RELATED COMPOUNDS AS TRPV1 VANILLOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PAIN Abbott Laboratories (US) 2009-12-23 EP disclosed
WO-2008079683-A2 N- (5, 6, 7, 8-TETRAHYDRONAPHTHALEN-1-YL) UREA DERIVATIVES AND RELATED COMPOUNDS AS TRPV1 VANILLOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PAIN ABBOTT LABORATORIES (US) 2008-07-03 WO disclosed